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Condensed Matter > Statistical Mechanics
Title: Optimal Control of the F${_1}$-ATPase Molecular Motor
(Submitted on 5 Oct 2022 (v1), last revised 28 Dec 2022 (this version, v2))
Abstract: F$_{1}$-ATPase is a rotary molecular motor that \emph{in vivo} is subject to strong nonequilibrium driving forces. There is great interest in understanding the operational principles governing its high efficiency of free-energy transduction. Here we use a near-equilibrium framework to design a non-trivial control protocol to minimize dissipation in rotating F$_{1}$ to synthesize ATP. We find that the designed protocol requires much less work than a naive (constant-velocity) protocol across a wide range of protocol durations. Our analysis points to a possible mechanism for energetically efficient driving of F$_{1}$ \emph{in vivo} and provides insight into free-energy transduction for a broader class of biomolecular and synthetic machines.
Submission history
From: Deepak Gupta [view email][v1] Wed, 5 Oct 2022 07:51:26 GMT (4528kb,D)
[v2] Wed, 28 Dec 2022 11:16:14 GMT (4530kb,D)
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