Title: Mining higher-order triadic interactions

Abstract: Complex systems often present higher-order interactions which require us to go beyond their description in terms of pairwise networks. Triadic interactions are a fundamental type of higher-order interaction that occurs when one node regulates the interaction between two other nodes. Triadic interactions are a fundamental type of higher-order networks, found in a large variety of biological systems, from neuron-glia interactions to gene-regulation and ecosystems. However, triadic interactions have been so far mostly neglected. In this article, we propose a theoretical principle to model and mine triadic interactions from node metadata, and we apply this framework to gene expression data finding new candidates for triadic interactions relevant for Acute Myeloid Leukemia. Our work reveals important aspects of higher-order triadic interactions often ignored, which can transform our understanding of complex systems and be applied to a large variety of systems ranging from biology to the climate.